Causes of early Alzheimer's in young people and risk factors

Causes of early Alzheimer's in young people and risk factors

Alzheimer's disease is what scares people most when they are old, but it is sad to know that it may affect young people. Knowing the causes of early Alzheimer's in young people may contribute to reducing its incidence.

Alzheimer's disease is known to us that it is associated with advancing age and affects the elderly, but did you know that it affects young people as well? What are the most prominent causes of early Alzheimer's in young people?

Early Alzheimer's disease in young people

Alzheimer's disease is often associated with advancing age and old age, and it is a type of dementia. This disease is characterized by memory loss to some extent and affects the behavior and thinking of the patient so that he cannot remember people, events, and other things.

Several factors are involved in the emergence of the disease, including changes that occur in brain cells due to age, along with genetic factors, in addition to the person’s lifestyle and other external factors, such as having some diseases.

Age progression, specifically the age of 65 and over, is the most common stage at which Alzheimer’s disease occurs, but in a few times a person may develop early Alzheimer’s disease, symptoms may begin from the age of thirty, forty or fifty.

The causes of early Alzheimer's in young people are not yet known precisely, but there is a known risk factor that may be the cause of this, which is genetic factors.

How does early Alzheimer's disease occur in young people?

searching for Causes of early Alzheimer's disease in young people is a trend Scientific researchKnowing the causes of the disease helps in finding the appropriate treatment for it.

When examining a part of the brain cells affected by Alzheimer's disease, it was noticed that two things appeared in the cells of the healthy brain, but the brain with Alzheimer's disease had much more, namely plaques and tangles.

Plaques:

It arises when parts of the beta-amyloid protein unite. Beta-amyloid results from the breakdown of another, larger protein present in the lipid membrane surrounding neurons. Beta-amyloid clusters or plaques close the neural pathway between neurons through which nerve signals are transmitted in the synapse area, and this stimulates neurons. The immune system that creates inflammation and eats up the malfunctioning cells.

Tangles:

A protein called tau helps the nerve fibers to be straight, and thus nutrients and other important substances can pass between neurons in the brain. At some point, the tau protein breaks down and the fibers become twisted instead of being straight, and here they are called tangles, because of the formation of these tangles, the materials will not reach nerve cells that will die later.

We observe the formation of amyloid plaques on nerve cells and the shrinkage of neuronal matter in the brain of a young man with early Alzheimer's.
The difference between a normal brain and a brain with Alzheimer's disease

Symptoms of early Alzheimer's in young people

Symptoms of early Alzheimer's disease in young people are similar to Alzheimer's symptoms in adults, and symptoms are divided into early symptoms and late symptoms, but we will not go into these divisions.

the Symptoms of early Alzheimer's in young people are one of the following:

  • Not remembering and forgetting important things, especially newly learned information, in addition to forgetting important dates
  • Repeating inquiries about things that have been asked about repeatedly
  • Inability to solve simple basic problems due to loss of concentration such as searching for things, or forgetting what to do
  • Forgetting what date and time it is
  • Wondering how he got to where he is
  • Vision problems
  • Difficulty entering into a conversation with friends or family, and he may not be able to find appropriate expressions for what he wants to talk about
  • Putting things in places and places that are not their place, and forgetting their places
  • Changes in mood and personality, so he may withdraw a lot from social situations and possibly work
  • Late symptoms of early Alzheimer's disease in young adults
  • Severe mood swings and changes in behavior
  • Losing knowledge of time severely, and wondering about the events and how he got to his place
  • Suspicion of everyone around him even friends and family
  • Having difficulty speaking, perhaps even swallowing, or walking
  • severe memory loss

Read more about: Alzheimer's disease symptoms and causes.

Early diagnosis and treatment of Alzheimer's disease in young people

The signs of mental deterioration that we explained earlier are the first evidence of the possibility of early Alzheimer’s disease in young people. Also, the presence of a family history of the disease may help in diagnosing the disease. After that, several tests are performed in Turkey to confirm the disease, which are:

  • Some cognitive tests to see the strength of memory and to test some mental skills and the ability to solve problems.
  • Computed tomography or magnetic resonance imaging of the brain; This shows how much damage there is to brain cells.
Early-onset Alzheimer's disease is diagnosed in young people through cognitive tests and a CT or MRI scan
Research on early Alzheimer's and its detection in young people

As for Alzheimer's disease treatment in Turkey It is done through medications to replace the neurotransmitters responsible for the patient's attention and memory, or through mental exercises that activate the brain and stimulate it to think. Actually it has evolved Treatment in Turkey Significantly and began to introduce many devices and advanced technologies, including technology TPS transcranial pulse stimulation.

The most important causes of early Alzheimer's in young people

The causes of early Alzheimer’s disease in young people are not yet clear. It is not known why some young people are more likely to develop early Alzheimer’s disease than others, but there are some simple possibilities that may lead to this, as follows:

  • There are three genetic mutations, and the presence of one or more of them together may play a role in Alzheimer's disease. When one of the parents or grandparents has these mutations, it can be passed on to the grandchildren later. The presence of one or more of these mutations makes the person more susceptible to Alzheimer's disease. Early on, these mutations are: (APP, PSEN1, or PSEN2), but not everyone with one of these mutations can develop Alzheimer's disease because 11% early-onset Alzheimer's patients were found to have one or all of these mutations.
  • Having a parent or grandparent with early Alzheimer's disease in young people increases the chances of developing the disease in children and grandchildren.
While searching for the causes of early-onset Alzheimer's disease in young people, researchers found that people with early Alzheimer's disease have the APP-PSEN 1-PSEN 2 mutations, while those with late-onset Alzheimer's disease may have the APOE 4 mutation, or the cause may be unknown.
Image showing genetic mutations that are among the most important causes of early Alzheimer's in young people

Risk factors for early Alzheimer's disease

There are a group of factors that increase the chances of developing Alzheimer’s disease, whether it is for young people or for the elderly, and these risk factors are:

Having some chronic diseases

have found Studies The incidence of some diseases such as stroke, heart disease, and high blood pressure can increase the incidence of Alzheimer's disease.

Other diseases such as obesity Diabetes increases the risk factors for Alzheimer's disease.

Unhealthy lifestyle

There is a possibility that an incorrect lifestyle may lead a person to Alzheimer's disease, especially at an advanced age.

A healthy lifestyle is represented in: the right way of eating, exercising, sleeping well, and nourishing the mind with education or continuous knowledge, all of this can reduce the chances of developing Alzheimer’s disease, especially with age.

Genetic factors and family history of Alzheimer's disease are the most important causes of early Alzheimer's in young people. It is important to diagnose the disease early to help reduce the progression of the disease and try to treat the symptoms of the disease before the disease progresses.


Sources:

  1. Johns Hopkins Medicine
  2. Alzheimer's Association

Frequently Asked Questions:

There is no definitive and categorical treatment for the disease, but there are some approved medicines that would slow the progression of the disease, maintain the mental level of people and help them control their behavior, but this matter may work for only a few years, and scientists are still searching for everything new to treat Alzheimer's disease. .

Adopting a healthy and proper lifestyle, and avoiding behaviors that lead to heart disease, obesity and diabetes, can contribute to reducing the chances of contracting the disease, also following the onset of symptoms early may help a lot.

Early Alzheimer’s disease in young people may affect people at an early age, perhaps in their thirties or forties, and of course these people have jobs and jobs, so it would be better to choose a job that suits their mental and behavioral state and not stress themselves with more anxiety and thinking about work, with Reducing working hours.

Symptoms of the disease and its development may accelerate the death of the patient, the average age of the years that a patient with Alzheimer’s may live after contracting the disease may be 8-10 years, and may be more than that.

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